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SPRAVATO® (esketamine) CIII nasal spray

At Precise, we believe in utilizing all available treatment options including newer medications and modalities of treatment. That is why we have taken the steps necessary to become a certified Spravato treatment center.

What is SPRAVATO® (esketamine) CIII nasal spray?

SPRAVATO® is a prescription medicine, used along with an antidepressant

taken by mouth to treat:

  • Adults with treatment-resistant depression (TRD)

  • Depressive symptoms in adults with major depressive disorder (MDD) with

       suicidal thoughts or actions


What Can I Expect?

  • If your provider decides that SPRAVATO® is an appropriate treatment plan for you, your plan may look like the following. 

1. Consultation—Your first visit will be a consultation. Precise will receive your medical information from your healthcare provider, conduct its own assessment to determine if SPRAVATO® may be right for you, and verify your insurance information as part of the eligibility confirmation. If SPRAVATO® is recommended, a treatment plan will be built with you and Precise will enroll you in the SPRAVATO® Risk Evaluation and Mitigation Strategy (REMS) Program. You may start treatment on your next visit. You may also be able to get help with insurance matters, scheduling and treatment preparation.

2. Treatment Days—On treatment days, you will administer SPRAVATO® nasal spray yourself under the supervision of a provider at Precise, who will assess your blood pressure before and after you administer SPRAVATO® nasal spray.  Other important information about Treatment Days:

  • After you administer SPRAVATO® nasal spray yourself, there will be an observation period of at least two hours during which you will be allowed to rest comfortably while a provider monitors you for possible side effects.  

  • You can discuss with your provider at Precise the specific personal items you might like to bring with you. These items might include headphones, a music player, a tablet, crossword puzzles or a book to pass the time, and a blanket and pillow to help you relax.

  • Because of possible side effects affecting mental alertness and motor coordination, you won’t be able to drive, operate machinery, or do anything where you need to be completely alert until the next day, following a restful sleep. So you’ll need to plan for rides on treatment days.  

  • Sedation (feeling sleepy) and dissociation (feeling disconnected from yourself, your thoughts, feelings and things around you) are among the possible serious side effects during and after taking SPRAVATO®, and you should expect your provider to ask you about these possible side effects during this period.

  • You should expect to have your blood pressure checked periodically during the observation period, as some people treated with SPRAVATO® have a temporary increase in blood pressure after treatment.

  • You should discuss your plans for the remainder of the day with your provider.

  • Tell your healthcare provider if you have any side effect that bothers you or does not go away.


3. Treatment Duration—If prescribed, you'll take SPRAVATO® twice a week for the first month. During the second month, you’ll take it once a week. After that, you’ll take it once a week or once every two weeks. You will continue to take your oral antidepressant as prescribed.  You and your provider will decide how long you stay on SPRAVATO® based on how you respond to it and how stable that response is. Your provider will determine the dosing frequency based on how you feel.

Precise and its team have specific regulations that must be followed in SPRAVATO® treatment. Our team will go over those rules and regulations. ​

For more information, please call (601) 420-5810 or submit a request for an appointment below.

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